Atp8a2 Gene Summary [Mouse]
Enables aminophospholipid flippase activity. Involved in several processes, including detection of light stimulus involved in visual perception; positive regulation of cellular component organization; and sensory organ morphogenesis. Acts upstream of or within several processes, including determination of adult lifespan; eating behavior; and involuntary skeletal muscle contraction. Located in Golgi apparatus; endosome; and membrane. Is expressed in several structures, including nervous system; salivary gland; sensory organ; testis; and thymus. Used to study cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4. Orthologous to human ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp8a2 |
| Official Name | ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 [Source:MGI Symbol;Acc:MGI:1354710] |
| Ensembl ID | ENSMUSG00000021983 |
| Bio databases IDs | |
| Aliases | ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
| Synonyms | agil, AI415030, ATP, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2, ATPase phospholipid transporting 8A2, Atpc1b, ATPIB, CAMRQ4, IB, ML-1, wl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp8a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid transporter
- Phospholipid-translocating ATPase N-terminal
- protein binding
- E1-E2 ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- lipid transporter
- aminophospholipid transporter
- phospholipid-translocating P-type ATPase, flippase
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 4
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- cleft lip
- eating disorder
- COVID-19
- cleft palate
- peripheral neuropathy
regulates
- phosphatidylserine
- MAPK
role in cell
- proliferation
- number
- development
- electrophysiology
- abnormal morphology
- degeneration
- organization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp8a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- neurofilament cytoskeleton organization
- determination of adult lifespan
- negative regulation of cell proliferation
- neuron development
- involuntary skeletal muscle contraction
- skin development
- positive regulation of multicellular organism growth
- eating behavior
- neuromuscular process controlling posture
- phospholipid translocation
- axonogenesis
- inner ear morphogenesis
- positive regulation of phospholipid translocation
- retina layer formation
- response to auditory stimulus
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- endosome membrane
- Golgi apparatus
- cell projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- protein binding