Prc1 Gene Summary [Mouse]
Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upstream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prc1 |
| Official Name | protein regulator of cytokinesis 1 [Source:MGI Symbol;Acc:MGI:1858961] |
| Ensembl ID | ENSMUSG00000038943 |
| Bio databases IDs | |
| Aliases | protein regulator of cytokinesis 1 |
| Synonyms | ASE1, D7Ertd348e, MAP65, protein REGULATING CYTOKINESIS 1, protein regulator of cytokinesis 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Microtubule associated protein (MAP65/ASE1 family)
- protein binding
- identical protein binding
- kinesin binding
Pathways
Biological processes and signaling networks where the Prc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- rectum cancer
- squamous cell lung cancer
- non-small cell lung cancer
- pancreatic adenocarcinoma
- epithelial neoplasia
- colorectal cancer
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- organismal death
role in cell
- phosphorylation in
- invasion by
- migration
- number
- quantity
- organization
- proliferation
- ingression
- chromosome hypersegregation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- spindle apparatus
- Plasma Membrane
- contractile rings
- midbody
- microtubule bundles
- cytoplasmic bridges
- cytosol
- nucleoplasm
- spindle fibers
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic spindle elongation
- spindle midzone assembly involved in mitosis
- positive regulation of cell proliferation
- regulation of cytokinesis
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- contractile ring
- microtubule cytoskeleton
- spindle pole
- chromosome
- plasma membrane
- nucleoplasm
- spindle microtubule
- nucleus
- intercellular bridge
- cytoplasm
- spindle
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- kinesin binding
- microtubule binding