Atp12a Gene Summary [Mouse]
Predicted to enable P-type potassium:proton transporter activity and P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within potassium ion homeostasis and regulation of pH. Located in basolateral plasma membrane. Is expressed in several structures, including gut; metanephros; pituitary gland; reproductive system; and thymus. Orthologous to human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp12a |
| Official Name | ATPase, H+/K+ transporting, nongastric, alpha polypeptide [Source:MGI Symbol;Acc:MGI:1926943] |
| Ensembl ID | ENSMUSG00000022229 |
| Bio databases IDs | |
| Aliases | ATPase, H+/K+ transporting, nongastric, alpha polypeptide |
| Synonyms | ATP1AL1, ATPAL1, ATPase H+/K+ transporting non-gastric alpha2 subunit, ATPase, H+/K+ transporting, nongastric, alpha polypeptide, ATPase, H+/K+ transporting, nongastric, α polypeptide, ATPase, Hydrogen-Potassium, Alpha 2A Subunit, ATPase, Hydrogen-Potassium, α 2A Subunit, cHKA, HK, HKalpha2, H-K-ATPase, P-Atpase α, P-ATPase α subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- Na+/K+-exchanging ATPase
- heavy metal translocating P-type ATPase
- protein binding
- E1-E2 ATPase
- plasma-membrane proton-efflux P-type ATPase
- P-type ATPase of unknown pump specificity (type V)
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- transmembrane domain
- H+/K+-exchanging ATPase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Cation transporting ATPase, C-terminus
- haloacid dehalogenase-like hydrolase
Pathways
Biological processes and signaling networks where the Atp12a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- Crohn disease
- nonulcer dyspepsia
- erosive esophagitis
- schizophrenia
- gastroesophageal reflux
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- eosinophilic esophagitis
- systemic mastocytosis
regulates
- K+
role in cell
- pH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- actin cytoskeleton
- cytosol
- apical membrane
- basolateral membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp12a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- establishment or maintenance of transmembrane electrochemical gradient
- cellular sodium ion homeostasis
- regulation of pH
Cellular Component
Where in the cell the gene product is active
- hydrogen:potassium-exchanging ATPase complex
- actin cytoskeleton
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- sodium:potassium-exchanging ATPase activity
- metal ion binding
- hydrogen:potassium-exchanging ATPase activity