Sdcbp Gene Summary [Mouse]
Enables interleukin-5 receptor binding activity. Involved in positive regulation of cell growth; positive regulation of cell migration; and positive regulation of cell population proliferation. Acts upstream of or within Ras protein signal transduction. Part of interleukin-5 receptor complex. Is expressed in several structures, including central nervous system; heart; nose; skin; and urinary system. Orthologous to human SDCBP (syndecan binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdcbp |
| Official Name | syndecan binding protein [Source:MGI Symbol;Acc:MGI:1337026] |
| Ensembl ID | ENSMUSG00000028249 |
| Bio databases IDs | |
| Aliases | syndecan binding protein |
| Synonyms | LOC108350925, MDA-9, SDCBP1, ST1, SYCL, syndecan binding protein, Syntenin, syntenin-1, TACIP18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdcbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- frizzled binding
- cell adhesion molecule binding
- canonical PDZ domain
- ephrin receptor binding
- enzyme
- protein binding
- syndecan binding
- PDZ domain
- ionotropic glutamate receptor binding
- identical protein binding
- interleukin-5 receptor binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- neurexin binding
- cpPDZ_Deg_HtrA-like
- PDZ binding motif
- protein heterodimerization
- growth factor binding
Pathways
Biological processes and signaling networks where the Sdcbp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metastasis
- esophageal squamous cell carcinoma
- organismal death
- autosomal dominant Emery-Dreifuss muscular dystrophy
- urothelial carcinoma
- urothelial cancer
- esophageal squamous cell cancer
- Duchenne muscular dystrophy
- juvenile dermatomyositis
role in cell
- expression in
- signaling in
- activation in
- formation
- degradation in
- phosphorylation in
- ubiquitination in
- binding in
- growth
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- azurophil granule lumen
- Cytoplasm
- presynaptic regions
- Extracellular Space
- membrane surface
- cellular membrane
- Nucleus
- endosomes
- Mitochondria
- cell-cell contacts
- granules
- cytosol
- cytoplasmic face of plasma membrane
- microsome
- nucleoplasm
- nuclear envelope
- actin stress fibers
- membrane rafts
- filopodia
- perikaryon
- dendrites
- axon terminals
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdcbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- negative regulation of receptor internalization
- positive regulation of cell proliferation
- synaptic transmission
- Ras protein signal transduction
- substrate-dependent cell migration, cell extension
- protein targeting to membrane
- regulation of mitotic cell cycle
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cell growth
- positive regulation of JNK cascade
- actin cytoskeleton organization
- intracellular signal transduction
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular region
- interleukin-5 receptor complex
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- nuclear membrane
- adherens junction
- extracellular vesicular exosome
- cytoskeleton
- focal adhesion
- cytoplasm
- melanosome
- membrane
- membrane raft
- blood microparticle
- cytosol
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- identical protein binding
- growth factor binding
- cytoskeletal adaptor activity
- cell adhesion molecule binding
- ephrin receptor binding
- syndecan binding
- interleukin-5 receptor binding
- phosphatidylinositol-4,5-bisphosphate binding
- frizzled binding
- protein binding
- protein heterodimerization activity
- neurexin family protein binding