Cd3d Gene Summary [Mouse]
Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Involved in positive thymic T cell selection. Part of alpha-beta T cell receptor complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 19 and severe combined immunodeficiency. Orthologous to human CD3D (CD3 delta subunit of T-cell receptor complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd3d |
| Official Name | CD3 antigen, delta polypeptide [Source:MGI Symbol;Acc:MGI:88331] |
| Ensembl ID | ENSMUSG00000032094 |
| Bio databases IDs | |
| Aliases | CD3 antigen, delta polypeptide |
| Synonyms | CD3 antigen, delta polypeptide, CD3 antigen, δ polypeptide, CD3-DELTA, CD3 delta subunit of T-cell receptor complex, CD3-δ, CD3 δ subunit of T-cell receptor complex, IMD19, T3D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd3d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- immunoglobulin domain
- ectodomain
- Immunoreceptor tyrosine-based activation motif
- protein binding
- identical protein binding
- transmembrane receptor
- T-cell surface glycoprotein CD3 delta chain
Pathways
Biological processes and signaling networks where the Cd3d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CCR5 Signaling in Macrophages
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Dendritic Cell Maturation
- G Protein Signaling Mediated by Tubby
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Lipid Antigen Presentation by CD1
- NF-κB Signaling
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Primary Immunodeficiency Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- SAPK/JNK Signaling
- Systemic Lupus Erythematosus Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- B-cell childhood acute lymphoblastic leukemia
- precursor B-cell acute lymphoblastic leukemia
- grade 3b follicular lymphoma
- chronic periodontal disease
- relapsed B cell acute lymphoblastic leukemia
- sepsis
- B-cell acute lymphoblastic lymphoma
- lymphoblastic B-cell lymphoma
- T acute lymphoblastic leukemia
- insulin-dependent diabetes mellitus
role in cell
- quantity
- expression in
- phosphorylation in
- cell viability
- activation
- apoptosis
- number
- development
- differentiation
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- cell surface
- cellular membrane
- Nucleus
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd3d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adaptive immune response
- alpha-beta T cell activation
- cell surface receptor signaling pathway
- positive thymic T cell selection
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- clathrin-coated endocytic vesicle membrane
- cytoplasm
- external side of plasma membrane
- T cell receptor complex
- alpha-beta T cell receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane signaling receptor activity