Agpat5 Gene Summary [Mouse]
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agpat5 |
| Official Name | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) [Source:MGI Symbol;Acc:MGI:1196345] |
| Ensembl ID | ENSMUSG00000031467 |
| Bio databases IDs | |
| Aliases | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) |
| Synonyms | 1110013A05Rik, 1-acylglycerol-3-phosphate O-acyltransferase 5, 1AGPAT5, D8Ertd319e, FLJ11210, LPAATE, LPLAT5, RGD1306405 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agpat5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Acyltransferase C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- early onset hypertension
regulates
- adenosine triphosphate
- GCG
- phosphatidic acid
- acylglycerol
role in cell
- activation
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agpat5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acylglycerol metabolic process
- phospholipid biosynthetic process
- CDP-diacylglycerol biosynthetic process
- phosphatidylinositol acyl-chain remodeling
- hemopoietic progenitor cell differentiation
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- mitochondrion
- endomembrane system
- endoplasmic reticulum
- nucleolus
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- transferase activity, transferring acyl groups
- protein binding