Pycrl Gene Summary [Mouse]
Predicted to enable cytidine deaminase activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within cytidine deamination. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pycrl |
| Official Name | pyrroline-5-carboxylate reductase-like [Source:MGI Symbol;Acc:MGI:1913444] |
| Ensembl ID | ENSMUSG00000022571 |
| Bio databases IDs | |
| Aliases | pyrroline-5-carboxylate reductase-like |
| Synonyms | 1110058B13RIK, 2700073G24Rik, PYCRL, pyrroline-5-carboxylate reductase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pycrl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- cytidine deaminase
- pyrroline-5-carboxylate reductase
- NADP oxidoreductase coenzyme F420-dependent
- enzyme
- protein binding
- Pyrroline-5-carboxylate reductase dimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic bridges
- cytosol
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pycrl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-proline biosynthetic process
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- mitotic spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyrroline-5-carboxylate reductase activity
- protein binding