Mycn Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of reactive oxygen species metabolic process and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including negative regulation of astrocyte differentiation; positive regulation of cell population proliferation; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mycn |
| Official Name | v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived [Source:MGI Symbol;Acc:MGI:97357] |
| Ensembl ID | ENSMUSG00000037169 |
| Bio databases IDs | |
| Aliases | v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived |
| Synonyms | bHLHe37, c-nmyc, FGLDS1, MODED, MPAPA, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYCNsPEP, Nmuc1, NMYC, NMYC1, ODED, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mycn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- nuclear localization sequence
- transcription activation domain
- central domain
- leucine zipper domain
- Myc amino-terminal region
- protein binding
- sequence-specific DNA binding
- acidic domain
- DNA binding
- phosphorylation site
- Myc box II
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- kinase binding
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- basic domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Mycn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- single ventricle defect
- congestive heart failure
- cancer
- edema
- acute myeloid leukemia
- bleeding
- skin basal cell carcinoma
- basal cell skin cancer
- hyperplasia
phenotypes
- abnormal Wolffian duct morphology
- abnormal angiogenesis
- abnormal anterior cardinal vein morphology
- abnormal apical ectodermal ridge morphology
- abnormal brain morphology
- abnormal cardiac epithelial to mesenchymal transition
- abnormal cranial ganglia morphology
- abnormal dorsal aorta morphology
- abnormal embryo development
- abnormal embryonic neuroepithelial layer differentiation
- abnormal embryonic neuroepithelium morphology
- abnormal fetal cardiomyocyte proliferation
- abnormal forebrain development
- abnormal heart development
- abnormal intestinal epithelium morphology
- abnormal large intestine morphology
- abnormal lens vesicle development
- abnormal limb bud morphology
- abnormal limb development
- abnormal liver development
- abnormal liver morphology
- abnormal lung development
- abnormal lung morphology
- abnormal medulla oblongata morphology
- abnormal mesonephric mesenchyme morphology
- abnormal mesonephros morphology
- abnormal neural tube morphology
- abnormal optic vesicle formation
- abnormal stomach morphology
- abnormal vein morphology
- abnormal vertebrae morphology
- abnormal vertebral body development
- absent stomach
- absent vitelline blood vessels
- anemia
- common ventricle
- congestive heart failure
- decreased body length
- decreased embryo size
- decreased fetal size
- decreased hematopoietic stem cell number
- dilated dorsal aorta
- disorganized dorsal root ganglion
- dorsal root ganglion hypoplasia
- edema
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- first pharyngeal arch hypoplasia
- gonadal ridge hypoplasia
- hemorrhage
- impaired branching involved in bronchus morphogenesis
- increased hepatocyte apoptosis
- kinked tail
- liver hypoplasia
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- no spontaneous movement
- pale yolk sac
- postnatal lethality incomplete penetrance
- prenatal lethality complete penetrance
- pulmonary hypoplasia
- respiratory distress
- respiratory failure
- small dorsal root ganglion
- small heart
- small kidney
- small liver
- small trigeminal ganglion
- small vertebral body
- telencephalon hypoplasia
- thin myocardium
- thin myocardium compact layer
- trabecula carnea hypoplasia
- vertebral fusion
role in cell
- cell viability
- proliferation
- growth
- expression in
- invasion
- activation in
- degradation in
- cell death
- number
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mycn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- kinase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity