Atp5j Gene Summary [Mouse]
The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | Atp5j |
| Official Name | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F [Source:MGI Symbol;Acc:MGI:107777] |
| Ensembl ID | ENSMUSG00000022890 |
| Bio databases IDs | |
| Aliases | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F |
| Synonyms | ATP5, ATP5A, ATP5J, ATPM, ATP SYNTHASE, Atp synthase (f0f1), subunit f, ATP synthase peripheral stalk subunit F6, CF6, F6, LOC102551946 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp5j often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenosine-tetraphosphatase
- binding protein
- Mitochondrial ATP synthase coupling factor 6
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp5j gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myocardial infarction
- Alzheimer disease
- bipolar disorder
- Huntington disease
- epithelial cancer
- mucoepidermoid carcinoma
- chronic kidney disease
- salivary duct carcinoma
- salivary duct cancer
- acinar-cell carcinoma
regulates
- epoprostenol
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cristae-like membrane
- cell surface
- Extracellular Space
- Mitochondria
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp5j gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism