Atp5pf Gene Summary [Rat]
Contributes to ATP hydrolysis activity. Involved in several processes, including negative regulation of icosanoid secretion; positive regulation of heart rate; and response to muscle activity. Located in cell surface and extracellular space. Part of proton-transporting ATP synthase complex. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5pf |
| Official Name | ATP synthase peripheral stalk subunit F6 [Source:RGD Symbol;Acc:621376] |
| Ensembl ID | ENSRNOG00000001551 |
| Bio databases IDs | |
| Aliases | ATP synthase peripheral stalk subunit F6 |
| Synonyms | ATP5, ATP5A, ATP5J, ATPM, ATP SYNTHASE, Atp synthase (f0f1), subunit f, ATP synthase peripheral stalk subunit F6, CF6, F6, LOC102551946 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5pf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenosine-tetraphosphatase
- binding protein
- Mitochondrial ATP synthase coupling factor 6
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp5pf gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myocardial infarction
- Alzheimer disease
- bipolar disorder
- Huntington disease
- epithelial cancer
- mucoepidermoid carcinoma
- chronic kidney disease
- salivary duct carcinoma
- salivary duct cancer
- acinar-cell carcinoma
regulates
- epoprostenol
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cristae-like membrane
- cell surface
- Extracellular Space
- Mitochondria
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5pf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism