Rttn Gene Summary [Mouse]
Acts upstream of or within determination of left/right symmetry. Predicted to be located in centrosome and membrane. Predicted to be active in centriole and ciliary basal body. Is expressed in several structures, including branchial arch; embryo mesoderm; extraembryonic component; forelimb bud; and neural ectoderm. Orthologous to human RTTN (rotatin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rttn |
| Official Name | rotatin [Source:MGI Symbol;Acc:MGI:2179288] |
| Ensembl ID | ENSMUSG00000023066 |
| Bio databases IDs | |
| Aliases | rotatin |
| Synonyms | 4921538A15Rik, C530033I08Rik, D230040K24, MSSP, rotatin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rttn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Rotatin, an armadillo repeat protein, centriole functioning
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- basal bodies
- centrosome
- centriole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rttn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centriole replication
- microtubule basal body organization
- centriole-centriole cohesion
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- cytoplasm
- centriole
Molecular Function
What the gene product does at the molecular level
- protein binding