Kif23 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Located in intercellular bridge. Is expressed in several structures, including alimentary system; hindbrain; olfactory epithelium; submandibular gland primordium; and ventricular layer. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IIIa. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Kif23 |
| Official Name | kinesin family member 23 [Source:MGI Symbol;Acc:MGI:1919069] |
| Ensembl ID | ENSMUSG00000032254 |
| Bio databases IDs | |
| Aliases | kinesin family member 23 |
| Synonyms | 3110001D19Rik, C87313, CDA3, CDAIII, CDAN3, CDAN3A, CHO1, kinesin family member 23, Kinesin-like 5, KNSL5, MKLP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- Arf6-interacting domain of mitotic kinesin-like protein 1
- tail domain
- protein binding
- microtubule motor protein
- phosphorylation site
Pathways
Biological processes and signaling networks where the Kif23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- invasive breast cancer
- nonalcoholic fatty liver disease
- metastasis
- endometrial adenocarcinoma formation
- breast carcinoma
- invasive breast carcinoma
- organismal death
- congenital dyserythropoietic anemia type IIIa
role in cell
- expression in
- proliferation
- growth
- accumulation in
- migration
- growth in
- epithelial-mesenchymal transition
- quantity
- formation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- midbody center
- mitotic structure
- spindle apparatus
- Nucleus
- centrosome
- Mitochondria
- microtubules
- midbody
- Flemming body
- cytoplasmic bridges
- cytosol
- nucleoplasm
- membrane processes
- central spindle
- mitotic spindle
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle elongation
- spindle midzone assembly involved in mitosis
- cytokinesis after mitosis
- microtubule-based movement
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- focal adhesion
- mitotic spindle
- centralspindlin complex
- spindle
- cytosol
- kinesin complex
- midbody
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding