Rpa2 Gene Summary [Mouse]
Enables DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and regulation of double-strand break repair via homologous recombination. Predicted to be located in PML body and chromatin. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Is expressed in blastocyst; brain; compacted morula; heart; and spermatocyte. Orthologous to human RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpa2 |
| Official Name | replication protein A2 [Source:MGI Symbol;Acc:MGI:1339939] |
| Ensembl ID | ENSMUSG00000028884 |
| Bio databases IDs | |
| Aliases | replication protein A2 |
| Synonyms | p34Rpa2, REPA2, replication protein A2, Replication protein a, 30-kda subunit, Rf-A2, RPA32, RPA32/2, RPA34, RP-A p32, RP-A p34 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Replication protein A C terminal
- DNA binding domain
- protein phosphatase binding
- enzyme binding
- ssDNA-binding domain
- protein binding
- sequence-specific DNA binding
- core domain, functional
- telomeric DNA binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
- DNA binding
- damaged DNA binding
- single-stranded DNA binding
Pathways
Biological processes and signaling networks where the Rpa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- complete testicular feminization syndrome
- dyskeratosis congenita or telomere biology disorder
- alopecia areata
- plexiform neurofibroma
- infection by HIV
role in cell
- growth
- phosphorylation in
- apoptosis
- cell death
- DNA damage response
- synthesis in
- homologous recombination in
- association
- G1 phase
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- Cytoplasm
- cytoplasmic aggregates
- nuclear foci
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- mitotic cell cycle G1/S transition DNA damage checkpoint
- DNA replication
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- telomere maintenance
- regulation of DNA damage checkpoint
- regulation of double-strand break repair via homologous recombination
- mismatch repair
- protein localization to chromosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- nuclear body
- PML body
- DNA replication factor A complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- ubiquitin protein ligase binding
- protein binding
- telomeric DNA binding
- damaged DNA binding
- enzyme binding
- single-stranded DNA binding