Mospd1 Gene Summary [Mouse]
Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including brain; cranial ganglion; limb mesenchyme; tongue muscle; and vertebral axis musculature. Orthologous to human MOSPD1 (motile sperm domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mospd1 |
| Official Name | motile sperm domain containing 1 [Source:MGI Symbol;Acc:MGI:1917630] |
| Ensembl ID | ENSMUSG00000023074 |
| Bio databases IDs | |
| Aliases | motile sperm domain containing 1 |
| Synonyms | 1810018L05Rik, DJ473B4, Major Sperm Domain, motile sperm domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mospd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- MSP (Major sperm protein) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mospd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding