Adgrf4 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Is expressed in several structures, including genitourinary system; heart; lung; skin; and thymus. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrf4 |
| Official Name | adhesion G protein-coupled receptor F4 [Source:MGI Symbol;Acc:MGI:1925499] |
| Ensembl ID | ENSMUSG00000023918 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor F4 |
| Synonyms | 4632435A09RIK, adhesion G protein-coupled receptor F4, GPR115, PGR18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adgrf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding