Meox2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including angiogenesis; skeletal muscle tissue development; and somite specification. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and musculoskeletal system. Orthologous to human MEOX2 (mesenchyme homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meox2 |
| Official Name | mesenchyme homeobox 2 [Source:MGI Symbol;Acc:MGI:103219] |
| Ensembl ID | ENSMUSG00000036144 |
| Bio databases IDs | |
| Aliases | mesenchyme homeobox 2 |
| Synonyms | GAX, mesenchyme homeobox 2, MOX2, Mox2a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Meox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- organismal death
- congenital malformation
- uterine serous papillary cancer
- gait disturbance
- glioma
- glioma formation
- Hutchinson-Gilford progeria syndrome
- cyanosis
- squamous-cell carcinoma
role in cell
- expression in
- activation
- proliferation
- migration
- binding in
- activation in
- apoptosis
- morphology
- size
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Meox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- somite development
- angiogenesis
- limb development
- skeletal muscle tissue development
- somite specification
- palate development
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cell migration involved in sprouting angiogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity