Treml1 Gene Summary [Mouse]
Predicted to enable transmembrane signaling receptor activity. Involved in platelet activation. Located in cell surface and platelet alpha granule. Is expressed in liver lobe and testis. Orthologous to human TREML1 (triggering receptor expressed on myeloid cells like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Treml1 |
| Official Name | triggering receptor expressed on myeloid cells-like 1 [Source:MGI Symbol;Acc:MGI:1918576] |
| Ensembl ID | ENSMUSG00000023993 |
| Bio databases IDs | |
| Aliases | triggering receptor expressed on myeloid cells-like 1 |
| Synonyms | 5430401J17Rik, TLT-1, triggering receptor expressed on myeloid cells-like 1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Treml1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- immunoglobulin domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- TNF
- fibrinogen (family)
disease
- pulmonary alveolar hemorrhage
- bleeding
- thrombocytopenia
phenotypes
- decreased platelet aggregation
- hemorrhage
- increased bleeding time
- increased circulating D-dimer level
- increased susceptibility to endotoxin shock
- increased tumor necrosis factor secretion
- skin hemorrhage
- thrombocytopenia
role in cell
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Golgi Apparatus
- cytosol
- nuclear speckles
- alpha granules