Prss21 Gene Summary [Mouse]
Enables serine-type endopeptidase activity. Predicted to be involved in proteolysis and spermatogenesis. Located in membrane. Is expressed in ovary; secondary spermatocyte; and testis. Orthologous to human PRSS21 (serine protease 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prss21 |
| Official Name | protease, serine 21 [Source:MGI Symbol;Acc:MGI:1916698] |
| Ensembl ID | ENSMUSG00000024116 |
| Bio databases IDs | |
| Aliases | protease, serine 21 |
| Synonyms | 1700023E12Rik, Esp-1, mT4, Resp-1, serine protease 21, TESP5, testisin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prss21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- serine-type peptidase
- peptidase
- Domain of unknown function (DUF1986)
Pathways
Biological processes and signaling networks where the Prss21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- teratozoospermia
- oligozoospermia
- hairpin sperm flagellum
regulated by
- tosylphenylalanyl chloromethyl ketone
- tosyllysine chloromethyl ketone
- Pi PLC
- 4-aminobenzamidine
- ACE
- phenylmethylsulfonyl fluoride
- isoflurophate
role in cell
- formation
- abnormal morphology
- function
- detachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- outer membranes
- cellular membrane
- Endoplasmic Reticulum
- sperm tail
- sperm head
- cytoplasmic droplets