Ace Gene Summary [Mouse]
Enables metallocarboxypeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including angiotensin maturation; cell proliferation in bone marrow; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is active in extracellular region. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ace |
| Official Name | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874] |
| Ensembl ID | ENSMUSG00000020681 |
| Bio databases IDs | |
| Aliases | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
| Synonyms | ACE1, ACE isoform 3, Angiotensin converting enzyme, angiotensin I converting enzyme, CD143, DCP, DCP1, KININASE II, Peptidyldipeptidase I, StsRR92 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ace often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Angiotensin-converting enzyme
- peptidase
- G-protein-coupled receptor binding
- enzyme
- cytoplasmic domain
- zinc ion binding
- actin binding
- peptidyl-dipeptidase
- exopeptidase
- protein kinase binding
- metalloexopeptidase
- dipeptidase
- metallocarboxypeptidase
- protein binding
- tripeptidyl-peptidase
- metallopeptidase
- endopeptidase
- binding protein
- stalk region
- transmembrane domain
- active site
- peptidase GluZincin family
- cytosolic tail domain
- peptidyl-dipeptidase A
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Ace gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential hypertension
- neoplasia
- rheumatic carditis
- rheumatoid arthritis
- lymphoma
- cancer
- Burkitt lymphoma
- plasma cell myeloma
- ischemic stroke
- cardiovascular disorder
role in cell
- phosphorylation in
- apoptosis
- proliferation
- survival
- expression in
- formation
- differentiation
- production in
- activation
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- cellular membrane
- endosomes
- vesicles
- lysosome
- apical cell surfaces
- basolateral cell surfaces
- plasma membrane extracellular face
- basal membrane
- sperm midpiece
- brush border
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ace gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart contraction
- male gonad development
- embryo development ending in birth or egg hatching
- angiotensin maturation
- lung alveolus development
- response to hypoxia
- kidney development
- cellular response to glucose stimulus
- bradykinin catabolic process
- regulation of synaptic plasticity
- substance P catabolic process
- beta-amyloid metabolic process
- positive regulation of peptidyl-cysteine S-nitrosylation
- negative regulation of gene expression
- neutrophil mediated immunity
- response to laminar fluid shear stress
- arachidonic acid secretion
- regulation of heart rate by cardiac conduction
- positive regulation of neurogenesis
- organ regeneration
- response to nutrient levels
- cell proliferation in bone marrow
- positive regulation of vasoconstriction
- vasoconstriction
- response to xenobiotic stimulus
- eating behavior
- response to thyroid hormone stimulus
- peptide catabolic process
- regulation of renal output by angiotensin
- regulation of smooth muscle cell migration
- mononuclear cell proliferation
- regulation of vasoconstriction
- regulation of angiotensin metabolic process
- regulation of systemic arterial blood pressure by renin-angiotensin
- spermatogenesis
- angiotensin-mediated signaling pathway
- positive regulation of systemic arterial blood pressure
- negative regulation of glucose import
- hemopoietic stem cell differentiation
- female pregnancy
- angiogenesis involved in coronary vascular morphogenesis
- negative regulation of calcium ion import
- antigen processing and presentation of peptide antigen via MHC class I
- hormone metabolic process
- regulation of blood pressure
- hormone catabolic process
- posttranscriptional regulation of gene expression
- blood vessel remodeling
- positive regulation of apoptotic process
- proteolysis
- response to lipopolysaccharide
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- extracellular space
- extracellular vesicular exosome
- endosome
- brush border membrane
- sperm midpiece
- external side of plasma membrane
- extracellular region
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- zinc ion binding
- peptidyl-dipeptidase activity
- tripeptidyl-peptidase activity
- endopeptidase activity
- peptidase activity
- metalloendopeptidase activity
- exopeptidase activity
- metallopeptidase activity
- chloride ion binding
- calmodulin binding
- metallodipeptidase activity
- mitogen-activated protein kinase binding
- bradykinin receptor binding
- mitogen-activated protein kinase kinase binding