Zfp397 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; microtubule cytoskeleton; and nucleolus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF397 (zinc finger protein 397). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zfp397 |
| Official Name | zinc finger protein 397 [Source:MGI Symbol;Acc:MGI:1916506] |
| Ensembl ID | ENSMUSG00000024276 |
| Bio databases IDs | |
| Aliases | zinc finger protein 397 |
| Synonyms | 2810411K16Rik, 6720480F11Rik, Zfp397, zinc finger protein 397, ZNF47, ZSCAN15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp397 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- leucine rich region
- transcription regulator
- Zinc-finger double domain
- protein homodimerization
- SCAN domain
- protein binding
- protein heterodimerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp397 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cytosol
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity