Lmo4 Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and positive regulation of kinase activity. Acts upstream of or within several processes, including cell differentiation in spinal cord; thymus development; and ventricular septum development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study anencephaly. Orthologous to human LMO4 (LIM domain only 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmo4 |
| Official Name | LIM domain only 4 [Source:MGI Symbol;Acc:MGI:109360] |
| Ensembl ID | ENSMUSG00000028266 |
| Bio databases IDs | |
| Aliases | LIM domain only 4 |
| Synonyms | A730077C12Rik, Crp3, Etohi4, LIM domain only 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmo4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ankylosing spondylitis
- exencephaly
- schizophrenia
- spina bifida
- cerebral infarction
- neonatal late-onset sepsis
- eyelids open at birth
- glossopharyngeal-vagus nerve fusion
role in cell
- apoptosis
- expression in
- survival
- binding in
- quantity
- proliferation
- differentiation
- migration
- frequency
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytoplasmic aggregates
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmo4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell fate specification
- motor axon guidance
- spinal cord association neuron differentiation
- ventricular septum development
- ventral spinal cord interneuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord motor neuron cell fate specification
- thymus development
- negative regulation of transcription from RNA polymerase II promoter
- neural tube closure
- negative regulation of protein complex assembly
- positive regulation of kinase activity
- regulation of cell migration
- regulation of cell activation
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cell leading edge
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- metal ion binding