Zkscan1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early conceptus; genitourinary system; nervous system; and olfactory epithelium. Orthologous to human ZKSCAN1 (zinc finger with KRAB and SCAN domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zkscan1 |
| Official Name | zinc finger with KRAB and SCAN domains 1 [Source:MGI Symbol;Acc:MGI:1921820] |
| Ensembl ID | ENSMUSG00000029729 |
| Bio databases IDs | |
| Aliases | zinc finger with KRAB and SCAN domains 1 |
| Synonyms | 5930429A01Rik, 9130423L19Rik, 9230118B16Rik, KOX18, PHZ-37, zinc finger with KRAB and SCAN domains 1, ZNF139, ZNF36, ZSCAN33 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zkscan1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- leucine rich region
- transcription regulator
- Zinc-finger double domain
- SCAN domain
- protein binding
- KRAB (Kruppel-associated box) domain -A box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- coronary artery disease
- organismal death
- major depression
- idiopathic pulmonary fibrosis
- chronic obstructive pulmonary disease
- pulmonary fibrosis
- respiratory disorder
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zkscan1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity