Myo7b Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including actin filament organization; brush border assembly; and sensory perception of sound. Located in apical cytoplasm; brush border; and microvillus. Is expressed in genitourinary system and gut. Orthologous to human MYO7B (myosin VIIB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo7b |
| Official Name | myosin VIIB [Source:MGI Symbol;Acc:MGI:107709] |
| Ensembl ID | ENSMUSG00000024388 |
| Bio databases IDs | |
| Aliases | myosin VIIB |
| Synonyms | myosin VIIB, RGD1561153 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- Myosin and Kinesin motor domain
- peptidase
- protein binding
- Pleckstrin homology-like domain
- MyTH4 domain
- Myosin head (motor domain)
- Src Homology 3 domain superfamily
- IQ calmodulin-binding motif
- Calmodulin-binding motif
- Ubl1_cv_Nsp3_N-like
- tail domain
- FERM domain B-lobe
- Myosin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cancer
- renal clear cell adenocarcinoma
- epithelial cancer
- lymphomagenesis
- renal cell carcinoma
- renal cell cancer
- kidney carcinoma
- primary central nervous system lymphoma
- primary cancer
- central nervous system cancer
regulated by
- collagen type i (family)
- Caco2 cells
- RANBP3L
regulates
role in cell
- maturation
- assembly
- endocytosis by
- maturation in
- dynamics in
- dynamics
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical cytoplasm
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo7b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- cell differentiation
- actin filament organization
- endocytosis
- actin filament-based movement
- sensory organ development
Cellular Component
Where in the cell the gene product is active
- myosin complex
- brush border
- microvillus
- cytoplasm
- membrane
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein binding
- microfilament motor activity