Cdhr5 Gene Summary [Mouse]
Predicted to enable beta-catenin binding activity; calcium ion binding activity; and cell adhesion molecule binding activity. Predicted to be involved in intermicrovillar adhesion and regulation of microvillus length. Predicted to be located in apical plasma membrane; cell projection membrane; and clathrin-coated pit. Predicted to be active in plasma membrane. Is expressed in liver; lung; metanephros; placenta; and yolk sac. Orthologous to human CDHR5 (cadherin related family member 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdhr5 |
| Official Name | cadherin-related family member 5 [Source:MGI Symbol;Acc:MGI:1919290] |
| Ensembl ID | ENSMUSG00000025497 |
| Bio databases IDs | |
| Aliases | cadherin-related family member 5 |
| Synonyms | 1810074H01Rik, cadherin-related family member 5, MLPCDH, MUCDHL, MU-PCDH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdhr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Cornifin (SPRR) family
- cytoplasmic domain
- MAPK-interacting and spindle-stabilising protein-like
- beta-catenin binding
- cell adhesion molecule binding
- calcium ion binding
- Cadherin repeat-like domain
- protein binding
- Spt5 C-terminal nonapeptide repeat binding Spt4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal neoplasia
- gastrointestinal neoplasia
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- systemic sclerosis
- survival
- systemic lupus erythematosus
- hypothyroidism
regulates
role in cell
- proliferation
- aggregation
- activity
- assembly
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell-matrix contacts
- cellular membrane
- cell-cell contacts
- apical membrane
- microvilli tips
- brush border
- clathrin-coated pits
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdhr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- regulation of microvillus length
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- brush border membrane
- extracellular vesicular exosome
- microvillus
- coated pit
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- cell adhesion molecule binding
- beta-catenin binding