Psmg2 Gene Summary [Mouse]
Predicted to enable molecular adaptor activity. Acts upstream of or within mitotic spindle assembly checkpoint signaling and negative regulation of apoptotic process. Located in nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 4. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmg2 |
| Official Name | proteasome (prosome, macropain) assembly chaperone 2 [Source:MGI Symbol;Acc:MGI:1922901] |
| Ensembl ID | ENSMUSG00000024537 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) assembly chaperone 2 |
| Synonyms | 1700017I17Rik, CLAST3, HCCA3, HsT1707, MDS003, PAC2, Pba2, PRAAS4, proteasome assembly chaperone 2, proteasome (prosome, macropain) assembly chaperone 2, TNFSF5IP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- negative regulation of apoptotic process
- chaperone-mediated protein complex assembly
- proteasome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging