Nat1 Gene Summary [Mouse]
Enables arylamine N-acetyltransferase activity. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; brain; genitourinary system; submandibular gland; and thymus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT2 (N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nat1 |
| Official Name | N-acetyl transferase 1 [Source:MGI Symbol;Acc:MGI:97279] |
| Ensembl ID | ENSMUSG00000025588 |
| Bio databases IDs | |
| Aliases | N-acetyl transferase 1 |
| Synonyms | AAC1, arylamine N-acetyltransferase-1, MNAT, N-acetyl transferase 1, NATI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyltransferase
- N-hydroxyarylamine O-acetyltransferase
- arylamine N-acetyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal cancer
- major depression
role in cell
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- arylamine N-acetyltransferase activity