Prkcq Gene Summary [Mouse]
Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including positive regulation of T-helper 17 type immune response; regulation of cell-cell adhesion; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-2 production; and protein phosphorylation. Located in cytoplasm and immunological synapse. Is expressed in several structures, including adipose tissue; genitourinary system; gut; limb; and nervous system. Used to study retinal detachment. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkcq |
| Official Name | protein kinase C, theta [Source:MGI Symbol;Acc:MGI:97601] |
| Ensembl ID | ENSMUSG00000026778 |
| Bio databases IDs | |
| Aliases | protein kinase C, theta |
| Synonyms | A130035A12Rik, nPKC-theta, nPKC-θ, PKC-0, Pkcq, PKC-theta, PKC-θ, PRKCT, protein kinase C theta, protein kinase C, theta, protein kinase C θ, protein kinase C, θ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkcq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- regulatory domain
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- V1 region
- C1A domain
- protein binding
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- pseudosubstrate domain
- alcohol group acceptor phosphotransferase
- C1B domain
- protein kinase C
- sXXN motif
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Prkcq gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- eNOS Signaling
- ErbB4 Signaling
- Erythropoietin Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Signaling
- nNOS Signaling in Neurons
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Th2 Pathway
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- neoplasia
- septic shock
- insulin-dependent diabetes mellitus
- acute myeloid leukemia
- experimental autoimmune myocarditis
- leukemia
- experimental autoimmune encephalomyelitis
- arthritis
- asthma
role in cell
- growth
- migration
- invasion by
- production in
- survival
- apoptosis
- degradation in
- expression in
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- raft fractions
- detergent-insoluble fractions
- aggresome
- cytoskeleton
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- centrosome
- immunological synapses
- cytosol
- uropod
- neuromuscular junctions
- sarcolemma
- membrane rafts
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkcq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Fc-epsilon receptor signaling pathway
- axon guidance
- regulation of platelet aggregation
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- cell chemotaxis
- positive regulation of T-helper 17 type immune response
- positive regulation of T cell activation
- inflammatory response
- CD4-positive, alpha-beta T cell proliferation
- positive regulation of interleukin-17 production
- intracellular signal transduction
- positive regulation of interleukin-2 production
- positive regulation of T-helper 2 cell activation
- regulation of transcription, DNA-dependent
- negative regulation of insulin receptor signaling pathway
- positive regulation of telomerase activity
- membrane protein ectodomain proteolysis
- negative regulation of T cell apoptotic process
- regulation of cell growth
- positive regulation of telomere maintenance via telomerase
- peptidyl-serine phosphorylation
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- cytosol
- aggresome
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity
- protein kinase C activity