Jade1 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in several cellular components, including microtubule organizing center; nuclear speck; and plasma membrane. Predicted to be part of histone acetyltransferase complex. Is expressed in several structures, including early conceptus; embryo ectoderm; genitourinary system; head somite; and primitive streak. Orthologous to human JADE1 (jade family PHD finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jade1 |
| Official Name | jade family PHD finger 1 [Source:MGI Symbol;Acc:MGI:1925835] |
| Ensembl ID | ENSMUSG00000025764 |
| Bio databases IDs | |
| Aliases | jade family PHD finger 1 |
| Synonyms | D530048A03RIK, FLJ22479, jade family PHD finger 1, mKIAA1807, PHF17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jade1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- histone acetyltransferase
- PHD-like zinc-binding domain
- transcription co-activator
- PHD finger superfamily
- protein binding
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jade1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- chromatin remodeling
- regulation of cell growth
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- apoptotic process
- regulation of DNA biosynthetic process
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cilium basal body
- cytoplasm
- nuclear speck
- plasma membrane
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding
- histone acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)