JADE1 Gene Summary [Human]
Enables transcription coactivator activity. Involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including ciliary basal body; cytosol; and nuclear speck. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | JADE1 |
| Official Name | jade family PHD finger 1 [Source:HGNC Symbol;Acc:HGNC:30027] |
| Ensembl ID | ENSG00000077684 |
| Bio databases IDs | |
| Aliases | jade family PHD finger 1 |
| Synonyms | D530048A03RIK, FLJ22479, jade family PHD finger 1, mKIAA1807, PHF17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JADE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- histone acetyltransferase
- PHD-like zinc-binding domain
- transcription co-activator
- PHD finger superfamily
- protein binding
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JADE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- chromatin remodeling
- regulation of cell growth
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- apoptotic process
- regulation of DNA biosynthetic process
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cilium basal body
- cytoplasm
- nuclear speck
- plasma membrane
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding
- histone acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)