Kat7 Gene Summary [Mouse]
Enables histone H3K14 acetyltransferase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of erythrocyte differentiation; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Part of histone H3-K14 acetyltransferase complex. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kat7 |
| Official Name | K(lysine) acetyltransferase 7 [Source:MGI Symbol;Acc:MGI:2182799] |
| Ensembl ID | ENSMUSG00000038909 |
| Bio databases IDs | |
| Aliases | K(lysine) acetyltransferase 7 |
| Synonyms | HBO1, HBOA, K(lysine) acetyltransferase 7, LOC303470, lysine acetyltransferase 7, MYST2, MYST histone acetyltransferase 2, ZC2HC7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kat7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- CcmH_N
- Zinc finger, C2HC type
- NAT_SF
- MOZ/SAS family
- DNA replication origin binding
- enzyme
- protein binding
- MYST family zinc finger domain
Pathways
Biological processes and signaling networks where the Kat7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- COVID-19
- renal clear cell adenocarcinoma
- renal clear cell cancer
- chorioallantoic membrane fusion failure
- growth failure
- precursor B-cell acute lymphoblastic leukemia
- organismal death
role in cell
- apoptosis
- cell viability
- growth
- proliferation
- expression in
- differentiation
- number
- acetylation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kat7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- DNA repair
- response to sorbitol
- positive regulation of gene expression, epigenetic
- stress-activated protein kinase signaling cascade
- DNA replication
- regulation of DNA-dependent DNA replication initiation
- regulation of transcription, DNA-dependent
- positive regulation of DNA replication
- regulation of DNA replication
- regulation of nucleotide-excision repair
- regulation of transcription from RNA polymerase II promoter
- internal peptidyl-lysine acetylation
- regulation of cell growth
- natural killer cell differentiation
- regulation of DNA biosynthetic process
- response to hydroxyurea
- regulation of cell cycle
- response to dithiothreitol
- response to actinomycin D
- positive regulation of transcription elongation, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- chromosome, centromeric region
- nucleolus
- chromatin
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- H3 histone acetyltransferase activity
- zinc ion binding
- histone acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase activity (H3-K23 specific)
- histone acetyltransferase activity (H3-K4 specific)
- chromatin binding
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)
- histone acetyltransferase activity
- DNA replication origin binding
- transcription cofactor activity
- protein binding
- H4 histone acetyltransferase activity