Mob4 Gene Summary [Mouse]
Predicted to enable kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of hippo signaling. Is active in glutamatergic synapse and postsynapse. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human MOB4 (MOB family member 4, phocein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mob4 |
| Official Name | MOB family member 4, phocein [Source:MGI Symbol;Acc:MGI:104899] |
| Ensembl ID | ENSMUSG00000025979 |
| Bio databases IDs | |
| Aliases | MOB family member 4, phocein |
| Synonyms | 2610109B12RIK, 2C4D, CGI-95, MOB1, MOB3, MOB family member 4, phocein, Mobkl1, MOBKL3, phocein, PHOCN, PREI3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mob4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein binding activity, bridging
- protein binding
- Mob1/phocein family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- schizophrenia
- insomnia
- peripheral arterial disease
- pancreatic cancer
- glioblastoma
- glioblastoma cancer
- major depression
role in cell
- proliferation
- migration
- budding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- Golgi region
- perinuclear region
- postsynaptic region
- Golgi Apparatus
- cytosol
- dendritic spines
- growth cone
- neurites
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mob4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- Golgi cisterna membrane
- dendritic spine
- Golgi apparatus
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein binding, bridging
- kinase binding