Camk2a Gene Summary [Mouse]
Enables calcium/calmodulin-dependent protein kinase activity; calmodulin binding activity; and glutamate receptor binding activity. Involved in several processes, including peptidyl-threonine autophosphorylation; regulation of endocannabinoid signaling pathway; and regulation of synaptic vesicle docking. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; modulation of chemical synaptic transmission; and protein phosphorylation. Located in mitochondrion and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camk2a |
| Official Name | calcium/calmodulin-dependent protein kinase II alpha [Source:MGI Symbol;Acc:MGI:88256] |
| Ensembl ID | ENSMUSG00000024617 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase II alpha |
| Synonyms | Alpha CaMKII, Calcium/calmodulin-dependent protein kinase (cam kinase) α, calcium/calmodulin-dependent protein kinase II alpha, calcium/calmodulin-dependent protein kinase II α, Calmodulin kinase II, CAMKA, CaMKII, CaMKII alpha, CaMKIINalpha, CaMKII α, CaM kinase II α, mKIAA0968, MRD53, MRT63, PK2CDD, PKCCD, α CaMKII |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Camk2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- LXXLL motif
- regulatory domain
- Protein kinase domain
- identical protein binding
- ATP-binding pocket
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- self-association domain
- calmodulin binding
- autoregulatory domain
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- calmodulin binding domain
- receptor binding
- autophosphorylation site
- SnoaL-like domain
- protein binding
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein homodimerization
- NTF2_like
Pathways
Biological processes and signaling networks where the Camk2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Calcium Signaling
- Chemokine Signaling
- Circadian Rhythm Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Factors Promoting Cardiogenesis in Vertebrates
- Glioma Signaling
- GM-CSF Signaling
- GNRH Signaling
- HIF1α Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Reelin Signaling in Neurons
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Serotonin Receptor Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Wnt/Ca+ pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- Huntington disease
- bipolar disorder
- Alzheimer disease
- ulcerative colitis
- inflammatory bowel disease
- mental retardation
- psoriasis
- autosomal dominant mental retardation type 53
- autosomal recessive intellectual developmental disorder 63
role in cell
- expression in
- proliferation
- accumulation in
- phosphorylation in
- density
- apoptosis
- production in
- survival
- growth
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- endocytic vesicle membrane
- cilia
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- dendritic spines
- neurites
- synaptosomes
- synapse
- sarcoplasmic reticulum membrane
- perikaryon
- axons
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Camk2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- angiotensin-mediated signaling pathway
- positive regulation of calcium ion transport
- protein autophosphorylation
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- dendritic spine development
- positive regulation of JAK-STAT cascade
- negative regulation of hydrolase activity
- response to ischemia
- regulation of neuronal synaptic plasticity
- G1/S transition of mitotic cell cycle
- calcium ion transport
- positive regulation of cardiac muscle cell apoptotic process
- regulation of endocannabinoid signaling pathway
- cellular response to interferon-gamma
- peptidyl-serine phosphorylation
- regulation of neuron migration
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- calcium- and calmodulin-dependent protein kinase complex
- nucleus
- postsynaptic density
- cytoplasm
- mitochondrion
- dendritic spine
- cytosol
- neuron projection
- endocytic vesicle membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding
- ATP binding
- calmodulin binding
- identical protein binding
- protein binding
- protein homodimerization activity
- metal ion binding
- calmodulin-dependent protein kinase activity
- protein serine/threonine kinase activity
- kinase activity