Rpa1 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homeostasis of number of cells within a tissue; and in utero embryonic development. Located in lateral element and male germ cell nucleus. Is expressed in respiratory system; submandibular gland; testis; and ventricular layer. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpa1 |
| Official Name | replication protein A1 [Source:MGI Symbol;Acc:MGI:1915525] |
| Ensembl ID | ENSMUSG00000000751 |
| Bio databases IDs | |
| Aliases | replication protein A1 |
| Synonyms | 5031405K23Rik, Cb1-727, HSSB, MST075, p70Rpa1, PFBMFT6, REPA1, replication protein A1, RF-A, RP-A, RPA70 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RPA1 DNA binding domain C
- OB-fold nucleic acid binding domain
- DNA binding domain
- protein binding activity, bridging
- chromatin binding
- protein binding
- sequence-specific DNA binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
- telomeric DNA binding
- Replication protein A OB domain
- Replication factor-A C terminal domain
- damaged DNA binding
- single-stranded DNA binding
- replication factor-a protein 1 (rpa1)
- E3 ubiquitin ligase domain
Pathways
Biological processes and signaling networks where the Rpa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- B cell cancer
- prostatic carcinoma
- lymphomagenesis
- telomere-related pulmonary fibrosis and/or bone marrow failure syndrome type 6
- Sézary syndrome
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- apoptosis
- proliferation
- cell death
- cell viability
- phosphorylation in
- activation in
- binding in
- recruitment in
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- Cytoplasm
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- base-excision repair
- DNA replication
- DNA-dependent DNA replication
- DNA recombination
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- telomere maintenance via telomerase
- telomere maintenance
- mismatch repair
- response to DNA damage stimulus
- chromatin organization
- meiotic cell cycle
- protein localization to chromosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- PML body
- DNA replication factor A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- single-stranded telomeric DNA binding
- damaged DNA binding
- single-stranded DNA binding