Dnaaf6 Gene Summary [Mouse]
Enables protein-folding chaperone binding activity. Acts upstream of or within axonemal dynein complex assembly and flagellated sperm motility. Located in cytoplasm. Is expressed in spermatid; spermatocyte; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 36. Orthologous to human DNAAF6 (dynein axonemal assembly factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaaf6 |
| Official Name | dynein axonemal assembly factor 6 [Source:MGI Symbol;Acc:MGI:1921958] |
| Ensembl ID | ENSMUSG00000026063 |
| Bio databases IDs | |
| Aliases | dynein axonemal assembly factor 6 |
| Synonyms | 4930521A18Rik, Dnaaf6, dynein axonemal assembly factor 6, retrotransposed, Pih1d3 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnaaf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dynein intermediate chain binding
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- trans Golgi network