Dnai2 Gene Summary [Mouse]
Predicted to enable dynein heavy chain binding activity; dynein light chain binding activity; and microtubule motor activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to act upstream of or within cilium assembly and determination of left/right symmetry. Located in several cellular components, including axoneme; external side of plasma membrane; and glial cell projection. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dnai2 |
| Official Name | dynein axonemal intermediate chain 2 [Source:MGI Symbol;Acc:MGI:2685574] |
| Ensembl ID | ENSMUSG00000034706 |
| Bio databases IDs | |
| Aliases | dynein axonemal intermediate chain 2 |
| Synonyms | b2b3405Clo, C030015H18Rik, CILD9, DIC2, Dnaic2, dynein axonemal intermediate chain 2, dynein, axonemal, intermediate chain 2, Gm728, oda6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnai2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
- microtubule motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary ciliary dyskinesia
- primary ciliary dyskinesia type 9
- habitual abortion
- Alzheimer disease
regulates
- Axonemal Dynein Outer Arm
role in cell
- assembly
- movement
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- organelle
- cilia
- axonemes
- plasma membrane extracellular face
- sperm tail
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnai2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- outer dynein arm assembly
- cilium morphogenesis
- cilium movement
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- outer dynein arm
- axonemal dynein complex
- external side of plasma membrane
- sperm flagellum
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- microtubule motor activity
- protein binding
- dynein heavy chain binding
- dynein light chain binding