Dnai1 Gene Summary [Mouse]
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in insulin receptor signaling pathway. Acts upstream of or within determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and heart development. Located in several cellular components, including 9+2 motile cilium; centrosome; and glial cell projection. Is expressed in embryo; spermatozoon; and testis. Used to study Kartagener syndrome; primary ciliary dyskinesia 1; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnai1 |
| Official Name | dynein axonemal intermediate chain 1 [Source:MGI Symbol;Acc:MGI:1916172] |
| Ensembl ID | ENSMUSG00000061322 |
| Bio databases IDs | |
| Aliases | dynein axonemal intermediate chain 1 |
| Synonyms | 1110066F04Rik, b2b1526Clo, CILD1, DIC1, Dnaic1, dynein axonemal intermediate chain 1, dynein, axonemal, intermediate chain 1, ICS1, oda6, PCD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnai1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- protein binding
- motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Axonemal Dynein Outer Arm
disease
- primary ciliary dyskinesia
- Kartagener syndrome
- hereditary disorder
- primary ciliary dyskinesia 1
- astrocytosis
- hydrocephalus
- asthenozoospermia
role in cell
- motility
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- cytoskeleton
- Cytoplasm
- cilia
- centrosome
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnai1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- sperm motility
- outer dynein arm assembly
- insulin receptor signaling pathway
- epithelial cilium movement
- cilium movement
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- centrosome
- outer dynein arm
- cytoskeleton
- cilium
- extracellular region
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein heavy chain binding
- motor activity
- dynein light chain binding