Ak8 Gene Summary [Mouse]
Predicted to enable (d)CMP kinase activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Acts upstream of or within ventricular system development. Located in axoneme and sperm flagellum. Used to study hydrocephalus. Orthologous to human AK8 (adenylate kinase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak8 |
| Official Name | adenylate kinase 8 [Source:MGI Symbol;Acc:MGI:1916120] |
| Ensembl ID | ENSMUSG00000026807 |
| Bio databases IDs | |
| Aliases | adenylate kinase 8 |
| Synonyms | 1190002A17Rik, adenylate kinase 8, C9orf98, DDX31, RGD1303144 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ak8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- adenylate kinase
- AMP binding
- NK
- cytidylate kinase
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DD_R_PKA_DPY30-like
- protein binding
- AAA domain
Pathways
Biological processes and signaling networks where the Ak8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- axonemes
- cytosol
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ak8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- nucleoside monophosphate phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- sperm flagellum
- axoneme
Molecular Function
What the gene product does at the molecular level
- adenylate kinase activity
- cytidylate kinase activity
- ATP binding
- protein binding
- AMP binding
- nucleoside diphosphate kinase activity