Ube2z Gene Summary [Mouse]
Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human UBE2Z (ubiquitin conjugating enzyme E2 Z). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2z |
| Official Name | ubiquitin-conjugating enzyme E2Z [Source:MGI Symbol;Acc:MGI:1343160] |
| Ensembl ID | ENSMUSG00000014349 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2Z |
| Synonyms | C030047H17RIK, D11Moh35, HOYS7, RGD1308347, ubiquitin-conjugating enzyme E2Z, USE1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2z often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin conjugating enzyme
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2z gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- insomnia
- nonalcoholic fatty liver disease
- myocardial infarction
- cleft lip
- productive infection by HIV-1
role in cell
- accumulation in
- apoptosis
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2z gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of apoptotic process
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cysteine-type endopeptidase inhibitor activity
- binding, bridging