Prmt6 Gene Summary [Mouse]
Enables chromatin binding activity and histone H3R2 methyltransferase activity. Involved in negative regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within cellular senescence; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction by p53 class mediator. Predicted to be located in nucleolus and nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Prmt6 |
| Official Name | protein arginine N-methyltransferase 6 [Source:MGI Symbol;Acc:MGI:2139971] |
| Ensembl ID | ENSMUSG00000049300 |
| Bio databases IDs | |
| Aliases | protein arginine N-methyltransferase 6 |
| Synonyms | AW124876, BB233495, HRMT1L6, LOC108348173, protein arginine methyltransferase 6, protein arginine N-methyltransferase 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prmt6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- histone-arginine N-methyltransferase
- histone methyltransferase
- precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
- PRMT5 arginine-N-methyltransferase
- chromatin binding
- enzyme
- protein binding
- AdoMet_MTases
- protein-arginine N-methyltransferase
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- hepatic fibrosis
- gestational diabetes mellitus
- motor dysfunction
- X-linked bulbospinal atrophy
role in cell
- expression in
- proliferation
- differentiation
- organization
- activation in
- senescence in
- cell cycle progression
- migration by
- damage in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prmt6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- protein modification process
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- base-excision repair
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- cellular senescence
- regulation of megakaryocyte differentiation
- regulation of mitochondrion organization
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- protein binding
- histone binding
- histone methyltransferase activity (H4-R3 specific)
- protein-arginine omega-N monomethyltransferase activity
- histone methyltransferase activity
- protein-arginine N-methyltransferase activity
- histone methyltransferase activity (H3-R2 specific)
- chromatin binding
- histone methyltransferase activity (H2A-R3 specific)
- histone-arginine N-methyltransferase activity