Dolpp1 Gene Summary [Mouse]
Enables dolichyldiphosphatase activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Is expressed in alimentary system; liver; nervous system; respiratory system; and urinary system. Orthologous to human DOLPP1 (dolichyldiphosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dolpp1 |
| Official Name | dolichyl pyrophosphate phosphatase 1 [Source:MGI Symbol;Acc:MGI:1914093] |
| Ensembl ID | ENSMUSG00000026856 |
| Bio databases IDs | |
| Aliases | dolichyl pyrophosphate phosphatase 1 |
| Synonyms | 0610011H20RIK, dolichyldiphosphatase 1, dolichyl pyrophosphate phosphatase 1, LSFR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dolpp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- PAP2 superfamily
- enzyme
- PAP2_like
- dolichyldiphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dolpp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid biosynthetic process
- protein N-linked glycosylation
- dolichyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- dolichyldiphosphatase activity