Rpn2 Gene Summary [Mouse]
Predicted to enable ribosome binding activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in autophagosome membrane; endoplasmic reticulum; and nuclear body. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; ear; heart; and integumental system. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rpn2 |
| Official Name | ribophorin II [Source:MGI Symbol;Acc:MGI:98085] |
| Ensembl ID | ENSMUSG00000027642 |
| Bio databases IDs | |
| Aliases | ribophorin II |
| Synonyms | 1300012C06Rik, AV261018, RIBIIR, ribophorin II, RPN-II, SWP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- ribosome binding
- Oligosaccharyltransferase subunit Ribophorin II
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- adenoma formation
- invasive breast cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- metastasis
role in cell
- expression in
- proliferation
- glycolysis in
- survival
- cisplatin sensitivity
- degradation in
- reprogramming in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- inner nuclear membrane
- nuclear bodies
- autophagic vacuoles
- rough endoplasmatic reticulum
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- nuclear body
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- dolichyl-diphosphooligosaccharide-protein glycotransferase activity
- protein binding