DOLPP1 Gene Summary [Human]
A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | DOLPP1 |
| Official Name | dolichyldiphosphatase 1 [Source:HGNC Symbol;Acc:HGNC:29565] |
| Ensembl ID | ENSG00000167130 |
| Bio databases IDs | |
| Aliases | dolichyldiphosphatase 1, linked to Surfeit genes in Fugu rubripes 2 |
| Synonyms | 0610011H20RIK, dolichyldiphosphatase 1, dolichyl pyrophosphate phosphatase 1, LSFR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DOLPP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- PAP2 superfamily
- enzyme
- PAP2_like
- dolichyldiphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DOLPP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid biosynthetic process
- protein N-linked glycosylation
- dolichyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- dolichyldiphosphatase activity