Terb2 Gene Summary [Mouse]
Involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Acts upstream of or within meiosis I; oogenesis; and spermatogenesis. Located in chromosome, telomeric region and nuclear inner membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 59. Orthologous to human TERB2 (telomere repeat binding bouquet formation protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Terb2 |
| Official Name | telomere repeat binding bouquet formation protein 2 [Source:MGI Symbol;Acc:MGI:1921651] |
| Ensembl ID | ENSMUSG00000027229 |
| Bio databases IDs | |
| Aliases | telomere repeat binding bouquet formation protein 2 |
| Synonyms | 4933406J08Rik, C15orf43, LOC688057, SPGF59, telomere repeat binding bouquet formation protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Terb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Telomere-associated protein TERB2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- KDM2A
- MEIOSIN/STRA8
disease
- spermatogenic failure 59
phenotypes
- abnormal double-strand DNA break repair
- abnormal female meiosis
- abnormal synaptonemal complex
- absent ovarian follicles
- arrest of male meiosis
- azoospermia
- decreased ovary weight
- decreased testis weight
- female infertility
- increased male germ cell apoptosis
- male infertility
- small ovary
- small testis
role in cell
- formation
- synapsis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- inner nuclear membrane
- nuclear envelope
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Terb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic telomere clustering
- oogenesis
- attachment of telomeric heterochromatin to nuclear envelope
- spermatogenesis
- synaptonemal complex assembly
- synapsis
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding