Kdm2a Gene Summary [Mouse]
Enables unmethylated CpG binding activity. Involved in transcription initiation-coupled chromatin remodeling. Acts upstream of or within several processes, including epithelial tube morphogenesis; neuroepithelial cell differentiation; and regulation of gene expression. Located in chromatin. Is expressed in embryo; forebrain; and limb. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm2a |
| Official Name | lysine (K)-specific demethylase 2A [Source:MGI Symbol;Acc:MGI:1354736] |
| Ensembl ID | ENSMUSG00000054611 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific demethylase 2A |
| Synonyms | 5530401A10RIK, AA589516, AW536790, CXXC8, FBL11, FBL7, F-box protein FBL7, FBXL11, Gm4560, Jhdm1, JHDM1A, lalina, LILINA, lysine demethylase 2A, lysine (K)-specific demethylase 2A, Ndy2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- F-box domain superfamily
- CTD_KDM2A_2B-like
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- RmlC-like cupin superfamily
- PHD-finger
- unmethylated CpG binding
- F-box domain
- zinc ion binding
- F-box-like
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- tumorigenesis
- prostatic carcinoma
- prostate cancer
- glioma
- glioma formation
- diabetic foot ulcer disorder
- angioedema
- growth failure
- neurodevelopmental disorder
role in cell
- apoptosis
- proliferation
- expression in
- activation in
- binding in
- differentiation
- breakage in
- senescence
- immortalization
- monomethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- circadian regulation of gene expression
- protein demethylation
- negative regulation of transcription by competitive promoter binding
- regulation of circadian rhythm
- double-strand break repair via nonhomologous end joining
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription cofactor activity
- unmethylated CpG binding
- histone demethylase activity
- histone demethylase activity (H3-K36 specific)