Mgme1 Gene Summary [Mouse]
Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in mitochondrial DNA repair and mitochondrial DNA replication. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 11. Orthologous to human MGME1 (mitochondrial genome maintenance exonuclease 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgme1 |
| Official Name | mitochondrial genome maintenance exonuclease 1 [Source:MGI Symbol;Acc:MGI:1921778] |
| Ensembl ID | ENSMUSG00000027424 |
| Bio databases IDs | |
| Aliases | mitochondrial genome maintenance exonuclease 1 |
| Synonyms | 8430406I07Rik, bA504H3.4, C20orf72, DDK1, mitochondrial genome maintenance exonuclease 1, MTDPS11, RGD1307465 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgme1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- flap endonuclease
- protein binding
- single-stranded DNA specific 5'-3' exodeoxyribonuclease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgme1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial DNA repair
- mitochondrial DNA replication
- mitochondrial genome maintenance
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- single-stranded DNA specific exodeoxyribonuclease activity
- single-stranded DNA specific 5'-3' exodeoxyribonuclease activity