Tert Gene Summary [Mouse]
Enables telomerase RNA binding activity; telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of D-glucose import. Located in mitochondrion and plasma membrane. Part of telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tert |
| Official Name | telomerase reverse transcriptase [Source:MGI Symbol;Acc:MGI:1202709] |
| Ensembl ID | ENSMUSG00000021611 |
| Bio databases IDs | |
| Aliases | telomerase reverse transcriptase |
| Synonyms | CMM9, DKCA2, DKCB4, EST2, hEST2, HTERT, hTRT, PFBMFT1, TCS1, TELOMERASE, Telomerase Catalytic Subunit, Telomerase Reverse Transcriptase, TP2, TR, TRT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tert often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- nucleotidyltransferase
- HLA-A24 binding motif
- transcription factor binding
- enzyme
- telomerase specific domain
- proline rich domain
- identical protein binding
- telomeric DNA binding
- RNA-directed DNA polymerase
- chaperone binding
- reverse transcriptase domain
- tRNA binding
- Telomerase ribonucleoprotein complex - RNA binding domain
- catalytic domain
- protein binding
- reverse transcriptase-like domain
- DNA binding
- RNA binding
- RNA-directed RNA polymerase
- primer grip domain
- ps-ssRNAv_RdRp-like
- protein homodimerization
- C-terminal extension
- telomerase
- TEN domain
- RNA-binding domain
- DAT domain
Pathways
Biological processes and signaling networks where the Tert gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- tumorigenesis
- epithelial neoplasia
- lung cancer
- thoracic cancer
- epithelial cancer
- neoplasia
- acute myeloid leukemia
- telomere-related pulmonary fibrosis and/or bone marrow failure 1
- enteropathy-associated T-cell lymphoma
role in cell
- quantity
- cell death
- phosphorylation in
- expression in
- accumulation in
- transactivation in
- production in
- activation
- growth
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- Mitochondria
- metaphase plate
- cytosol
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear speckles
- Cajal bodies
- mitoplasts
- PML nuclear bodies
- mitotic spindle
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tert gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hair cycle
- positive regulation of protein binding
- replicative senescence
- positive regulation of angiogenesis
- negative regulation of neuron apoptotic process
- positive regulation of nitric-oxide synthase activity
- establishment of protein localization to telomere
- transcription, RNA-dependent
- DNA biosynthetic process
- negative regulation of endothelial cell apoptotic process
- cellular response to hypoxia
- production of siRNA involved in RNA interference
- negative regulation of cellular senescence
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of G1/S transition of mitotic cell cycle
- DNA strand elongation
- RNA-dependent DNA replication
- telomere maintenance
- telomere maintenance via telomerase
- positive regulation of glucose import
- response to cadmium ion
- mitochondrion organization
- negative regulation of gene expression
- regulation of protein stability
- positive regulation of stem cell proliferation
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- PML body
- nuclear speck
- telomerase holoenzyme complex
- nucleolus
- plasma membrane
- telomerase catalytic core complex
- mitochondrial nucleoid
- nucleoplasm
- nuclear telomere cap complex
- chromosome, telomeric region
- nucleus
- cytosol
- RNA-directed RNA polymerase complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- tRNA binding
- transcription coactivator binding
- telomerase activity
- DNA binding
- telomeric template RNA reverse transcriptase activity
- RNA-directed DNA polymerase activity
- protein binding
- RNA binding
- telomeric RNA binding
- telomeric DNA binding
- metal ion binding
- RNA-directed RNA polymerase activity
- chaperone binding