Nupr1 Gene Summary [Mouse]
Enables acetyltransferase activator activity and chromatin binding activity. Involved in several processes, including negative regulation of epithelial cell apoptotic process; negative regulation of type B pancreatic cell proliferation; and positive regulation of neuroinflammatory response. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of fibroblast proliferation; and positive regulation of fibroblast apoptotic process. Predicted to be located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; jaw; orbito-sphenoid; pancreas; and sensory organ. Used to study Sertoli cell-only syndrome. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nupr1 |
| Official Name | nuclear protein transcription regulator 1 [Source:MGI Symbol;Acc:MGI:1891834] |
| Ensembl ID | ENSMUSG00000030717 |
| Bio databases IDs | |
| Aliases | nuclear protein transcription regulator 1 |
| Synonyms | 2310032H04Rik, COM1, nuclear protein 1, transcriptional regulator, nuclear protein transcription regulator 1, Nupr1l1, P8, Protein p8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nupr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- DNA-binding nuclear phosphoprotein p8
- chromatin binding
- protein binding
- enzyme activator activity
- DNA binding
Pathways
Biological processes and signaling networks where the Nupr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- tumorigenesis
- major depression
- non-small cell lung cancer
- chronic obstructive pulmonary disease
- azoospermia
role in cell
- growth
- expression in
- differentiation
- apoptosis
- binding in
- proliferation
- migration
- number
- cell viability
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytoplasmic bridges
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nupr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- negative regulation of cell proliferation
- negative regulation of cell cycle
- negative regulation of glycolysis
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of cell cycle
- response to toxin
- positive regulation of neuron apoptotic process
- fibroblast proliferation
- skeletal muscle cell differentiation
- negative regulation of fibroblast proliferation
- positive regulation of transcription, DNA-dependent
- positive regulation of intrinsic apoptotic signaling pathway
- macromolecular complex assembly
- regulation of female gonad development
- positive regulation of fibroblast apoptotic process
- fibroblast apoptotic process
- negative regulation of sequence-specific DNA binding transcription factor activity
- acute inflammatory response
- negative regulation of autophagy
- negative regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- regulation of autophagy
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of protein modification process
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- perinuclear region of cytoplasm
- cytoplasm
- protein-DNA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- acetyltransferase activator activity
- chromatin binding