Rtf2 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to be involved in cellular response to hydroxyurea and regulation of DNA stability. Predicted to be located in replication fork. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human RTF2 (replication termination factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtf2 |
| Official Name | replication termination factor 2 [Source:MGI Symbol;Acc:MGI:1913654] |
| Ensembl ID | ENSMUSG00000027502 |
| Bio databases IDs | |
| Aliases | replication termination factor 2 |
| Synonyms | 1700067C04Rik, 2410001C21Rik, 5730427M17Rik, AURA10, C20orf43, CDAO5, HSPC164, replication termination factor 2, replication termination factor 2 domain containing 1, RGD1311072, RTFDC1, SHUJUN-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Rtf2 RING-finger
- protein binding
- DNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication termination
- cellular response to hydroxyurea
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding