RTF2 Gene Summary [Human]
Enables DNA binding activity. Involved in cellular response to hydroxyurea and regulation of DNA stability. Located in replication fork. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RTF2 |
| Official Name | replication termination factor 2 [Source:HGNC Symbol;Acc:HGNC:15890] |
| Ensembl ID | ENSG00000022277 |
| Bio databases IDs | |
| Aliases | replication termination factor 2 |
| Synonyms | 1700067C04Rik, 2410001C21Rik, 5730427M17Rik, AURA10, C20orf43, CDAO5, HSPC164, replication termination factor 2, replication termination factor 2 domain containing 1, RGD1311072, RTFDC1, SHUJUN-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RTF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Rtf2 RING-finger
- protein binding
- DNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RTF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication termination
- cellular response to hydroxyurea
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding