Cc2d1b Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytosol and endosome membrane. Is expressed in facial ganglion; glossopharyngeal ganglion; trigeminal ganglion; and vagus ganglion. Orthologous to human CC2D1B (coiled-coil and C2 domain containing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cc2d1b |
| Official Name | coiled-coil and C2 domain containing 1B [Source:MGI Symbol;Acc:MGI:2443076] |
| Ensembl ID | ENSMUSG00000028582 |
| Bio databases IDs | |
| Aliases | coiled-coil and C2 domain containing 1B |
| Synonyms | A830039B04Rik, coiled-coil and C2 domain containing 1B, FREUD-2, Lgd1, RGD1306630 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cc2d1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- endosomal membrane
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cc2d1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- endosome membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity